Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4921733 | 0.72 | CRBN (0.41) | CRBNKDM4EMAPTALDH1A1DHFR | |
| SCHEMBL12427186 | 0.61 | CRBN (0.53) | CRBNKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL12104232 | 0.60 | CRBN (0.65) | CRBNALDH1A1SMN1; SMN2PLD1 | |
| SCHEMBL29631825 | 0.60 | HRH1 (0.57) | ALDH1A1LMNANPC1RAB9ATDP1 | |
| SCHEMBL12803074 | 0.60 | HRH1 (0.57) | ALDH1A1LMNANPC1RAB9ATDP1 | |
| SCHEMBL2198674 | 0.59 | CRBN (0.63) | CRBNALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL30702779 | 0.59 | CRBN (0.63) | CRBNALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL21353591 | 0.59 | — | — | |
| SCHEMBL29857922 | 0.59 | PLD1 (0.73) | KDM4EMAPTALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL15800694 | 0.59 | PLD1 (0.73) | KDM4EMAPTALDH1A1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977334-B2 | N-(3-{2-[3-(6-amino-benzimidazol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide; beta(3)-Adrenoceptor agonists; antidiabetic, obesity modulator, insulin resistance | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-12 | — | — | US | disclosed |