SCHEMBL21988152

SCHEMBL21988152

CCCCCN1C(=O)c2cccc3c(Br)ccc(c23)C1=O

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.72
MEN1 O00255 2/20 0.72
MAPT P10636 2/20 0.72
KMT2A Q03164 2/20 0.72
ALDH1A1 P00352 2/20 0.72
KDM4E B2RXH2 1/20 0.72
NPC1 O15118 1/20 0.72
LMNA P02545 1/20 0.72
PABPC1 P11940 1/20 0.72
CYP1B1 Q16678 15/20 0.72
RGS12 O14924 1/20 0.60
USP2 O75604 1/20 0.60
MAPK1 P28482 1/20 0.60
HTT P42858 1/20 0.60
ATM Q13315 1/20 0.60
NPSR1 Q6W5P4 1/20 0.60
TLR9 Q9NR96 1/20 0.60
TDP1 Q9NUW8 1/20 0.60
L3MBTL1 Q9Y468 1/20 0.60
RXFP1 Q9HBX9 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30096317 0.99 POLB (0.70) POLBMEN1MAPTKMT2AALDH1A1
SCHEMBL31146710 0.99 POLB (0.70) POLBMEN1MAPTKMT2AALDH1A1
SCHEMBL21988126 0.99 POLB (0.70) POLBMEN1MAPTKMT2AALDH1A1
SCHEMBL23295234 0.99 POLB (0.70) POLBMEN1MAPTKMT2AALDH1A1
SCHEMBL28412907 0.99 POLB (0.70) POLBMEN1MAPTKMT2AALDH1A1
SCHEMBL23295238 0.99 POLB (0.70) POLBMEN1MAPTKMT2AALDH1A1
SCHEMBL21988116 0.99 POLB (0.70) POLBMEN1MAPTKMT2AALDH1A1
SCHEMBL6548561 0.99 POLB (0.70) POLBMEN1MAPTKMT2AALDH1A1
SCHEMBL3773566 0.96 POLB (0.74) POLBMEN1MAPTKMT2AALDH1A1
SCHEMBL30499259 0.96 POLB (0.74) POLBMEN1MAPTKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200172489-A1 FLUORESCENT COMPOUND AND AUTOPHAGY DETECTION REAGENT USING SAME DOJINDO LABORATORIES (JP) 2020-06-04 US disclosed
CN-110650946-A Fluorescent compound and autophagy detection reagent using same 株式会社同仁化学研究所 2020-01-03 CN disclosed
CN-103923008-B 1, 8-naphthalimide derivative with fluorescent whitening property and preparation method thereof UNIV FUZHOU 2015-07-22 CN disclosed
CN-103923008-A 1, 8-naphthalimide derivative with fluorescent whitening property and preparation method thereof UNIV FUZHOU 2014-07-16 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200172489-A1 FLUORESCENT COMPOUND AND AUTOPHAGY DETECTION REAGENT USING SAME NR2E3, GPR6, ATG13 POLB 4315/4885MEN1 3491/4885MAPT 2166/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.