Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21990479 | 0.77 | PIK3CA (0.36) | ALDH1A1L3MBTL1 | |
| SCHEMBL21990483 | 0.72 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1NPSR1KDM4E | |
| SCHEMBL31390113 | 0.65 | NPSR1 (0.45) | ALDH1A1L3MBTL1NPSR1KDM4ESMN1; SMN2 | |
| SCHEMBL29383162 | 0.65 | NPSR1 (0.45) | ALDH1A1L3MBTL1NPSR1KDM4ESMN1; SMN2 | |
| SCHEMBL14354189 | 0.65 | NPSR1 (0.45) | ALDH1A1L3MBTL1NPSR1KDM4ESMN1; SMN2 | |
| SCHEMBL11023189 | 0.65 | NPSR1 (0.45) | ALDH1A1L3MBTL1NPSR1KDM4ESMN1; SMN2 | |
| SCHEMBL2133062 | 0.65 | NPSR1 (0.48) | ALDH1A1L3MBTL1NPSR1KDM4ESMN1; SMN2 | |
| SCHEMBL12182363 | 0.64 | KDM4E (0.45) | ALDH1A1L3MBTL1NPSR1KDM4ESMN1; SMN2 | |
| SCHEMBL26289357 | 0.64 | NPSR1 (0.47) | ALDH1A1L3MBTL1NPSR1KDM4ESMN1; SMN2 | |
| SCHEMBL14353990 | 0.63 | KDM4E (0.44) | ALDH1A1L3MBTL1NPSR1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880676-B1 | 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | PFIZER (US) | 2023-08-02 | — | — | EP | disclosed |
| US-11142525-B2 | Azalactam compounds as HPK1 inhibitors | PFIZER INC. (US) | 2021-10-12 | — | — | US | disclosed |
| US-20200172539-A1 | Azalactam Compounds as HPK1 Inhibitors | PFIZER INC. (US) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200172539-A1 | Azalactam Compounds as HPK1 Inhibitors | CDKN1A, HIPK1, CMPK1 | ALDH1A1 1686/4885L3MBTL1 2150/4885NPSR1 2490/4885 |
| US-11142525-B2 | Azalactam compounds as HPK1 inhibitors | CDKN1A, HIPK1, CMPK1 | ALDH1A1 1686/4885L3MBTL1 2150/4885NPSR1 2490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.