Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 9/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.30 |
| ▸ | RET | P07949 | 4/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.30 |
| ▸ | LCK | P06239 | 3/20 | 0.30 |
| ▸ | PIM1 | P11309 | 3/20 | 0.30 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.30 |
| ▸ | STK3 | Q13188 | 3/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.30 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.30 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.30 |
| ▸ | FLT4 | P35916 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21990468 | 0.82 | TAAR1 (0.34) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL22012276 | 0.80 | MAP4K1 (0.33) | CSF1RPARP1ROCK2RETAURKB | |
| SCHEMBL21990591 | 0.80 | GRM2 (0.33) | CSF1RKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL21990473 | 0.80 | PARP1 (0.31) | CSF1RPARP1 | |
| SCHEMBL21990474 | 0.76 | MAPK1 (0.34) | CSF1RPARP1 | |
| SCHEMBL30136111 | 0.72 | CACNA1G (0.37) | — | |
| SCHEMBL22012577 | 0.72 | CACNA1G (0.37) | — | |
| SCHEMBL21990516 | 0.72 | KDR (0.33) | CSF1RKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL21990542 | 0.72 | NPSR1 (0.35) | CSF1RPARP1KDRPIK3CDPIK3CA | |
| SCHEMBL21964197 | 0.71 | MAP4K1 (0.35) | PIK3CDPIK3CAPIK3CBPIK3CGPRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240197703-A1 | Azalactam Compounds as HPK1 Inhibitors | PFIZER INC. (US) | 2024-06-20 | — | — | US | disclosed |
| EP-3880676-B1 | 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | PFIZER (US) | 2023-08-02 | — | — | EP | disclosed |
| US-11684616-B2 | Azalactam compounds as HPK1 inhibitors | PFIZER INC. (US) | 2023-06-27 | — | — | US | disclosed |
| US-20220401424-A1 | Azalactam Compounds as HPK1 Inhibitors | PFIZER INC. (US) | 2022-12-22 | — | — | US | disclosed |
| US-11142525-B2 | Azalactam compounds as HPK1 inhibitors | PFIZER INC. (US) | 2021-10-12 | — | — | US | disclosed |
| US-20200172539-A1 | Azalactam Compounds as HPK1 Inhibitors | PFIZER INC. (US) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220401424-A1 | Azalactam Compounds as HPK1 Inhibitors | CDKN1A, HIPK1, CMPK1 | CSF1R 450/4885PARP1 966/4885KDR 1117/4885 |
| US-20200172539-A1 | Azalactam Compounds as HPK1 Inhibitors | CDKN1A, HIPK1, CMPK1 | CSF1R 410/4885PARP1 1047/4885KDR 969/4885 |
| US-11142525-B2 | Azalactam compounds as HPK1 inhibitors | CDKN1A, HIPK1, CMPK1 | CSF1R 410/4885PARP1 1047/4885KDR 969/4885 |
| US-11684616-B2 | Azalactam compounds as HPK1 inhibitors | CDKN1A, HIPK1, CMPK1 | CSF1R 450/4885PARP1 966/4885KDR 1117/4885 |
| US-20240197703-A1 | Azalactam Compounds as HPK1 Inhibitors | CDKN1A, HIPK1, CMPK1 | CSF1R 450/4885PARP1 966/4885KDR 1117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.