Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19564536 | 0.83 | HPGD (0.51) | HPGDRECQLEPHX1PTPN2PTPN1 | |
| SCHEMBL17713753 | 0.78 | HPGD (0.49) | HPGDRECQLEPHX1PTPN2PTPN1 | |
| SCHEMBL17713748 | 0.78 | HPGD (0.49) | HPGDRECQLEPHX1PTPN2PTPN1 | |
| SCHEMBL17725065 | 0.78 | HPGD (0.49) | HPGDRECQLEPHX1PTPN2PTPN1 | |
| SCHEMBL23826275 | 0.74 | HPGD (0.60) | HPGDRECQLEPHX1PTPN2PTPN1 | |
| SCHEMBL19626321 | 0.74 | HPGD (0.60) | HPGDRECQLEPHX1PTPN2PTPN1 | |
| SCHEMBL13599001 | 0.74 | HPGD (0.60) | HPGDRECQLEPHX1PTPN2PTPN1 | |
| SCHEMBL28195249 | 0.73 | HPGD (0.68) | HPGDRECQLEPHX1PTPN2PTPN1 | |
| SCHEMBL15918632 | 0.73 | HPGD (0.59) | HPGDRECQLEPHX1PTPN2PTPN1 | |
| SCHEMBL43357 | 0.72 | HPGD (0.66) | HPGDRECQLEPHX1PTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3317271-B1 | INHIBITORS OF EZH2 (ENHANCER OF ZESTE HOMOLOG 2) | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-05-13 | — | — | EP | disclosed |