Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23183120 | 0.91 | DRD2 (0.55) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL18633798 | 0.88 | DRD2 (0.55) | DRD2SLC18A3SMN1; SMN2CARM1PRMT6 | |
| SCHEMBL20965459 | 0.77 | KCNH2 (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL6198518 | 0.76 | DRD2 (0.55) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL6200948 | 0.76 | DRD2 (0.55) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL826215 | 0.76 | DRD2 (0.55) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL22307922 | 0.73 | DRD2 (0.66) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL23374660 | 0.73 | DRD2 (0.66) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL9912160 | 0.73 | DRD2 (0.66) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL20362574 | 0.73 | DRD2 (0.51) | DRD2DRD1DRD4DRD5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286166-B1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV HEALTHCARE UK NO 5 LTD (GB) | 2020-05-13 | — | — | EP | disclosed |