Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21992991 | 0.90 | TOP2A (0.64) | TOP2AMAPTXDHKDM4EALDH1A1 | |
| SCHEMBL21993446 | 0.87 | MAPT (0.58) | TOP2AMAPTXDHKDM4EALDH1A1 | |
| SCHEMBL21992969 | 0.83 | KDM4E (0.52) | TOP2AMAPTXDHKDM4EALDH1A1 | |
| SCHEMBL21993011 | 0.83 | KDM4E (0.48) | TOP2AMAPTXDHKDM4EALDH1A1 | |
| SCHEMBL21993053 | 0.81 | KDM4E (0.56) | TOP2AMAPTXDHKDM4EALDH1A1 | |
| SCHEMBL21993054 | 0.79 | TOP2A (0.45) | TOP2AMAPTXDHKDM4EALDH1A1 | |
| SCHEMBL21993030 | 0.77 | MAPT (0.55) | TOP2AMAPTXDHKDM4EALDH1A1 | |
| SCHEMBL21993259 | 0.76 | MAPT (0.60) | TOP2AMAPTXDHKDM4EALDH1A1 | |
| SCHEMBL21992973 | 0.75 | MAPT (0.58) | TOP2AMAPTXDHKDM4EALDH1A1 | |
| SCHEMBL21992947 | 0.75 | MAPT (0.58) | TOP2AMAPTXDHKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200147039-A1 | COMPOUNDS USEFUL IN INHIBITING HUMAN TREFOIL FACTOR 3 | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200147039-A1 | COMPOUNDS USEFUL IN INHIBITING HUMAN TREFOIL FACTOR 3 | ETF1, F3, DNASE1L3 | TOP2A 219/4885MAPT 4590/4885XDH 422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.