Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TOP2A | P11388 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21993046 | 0.90 | KDM4E (0.54) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL21993015 | 0.89 | TOP2A (0.54) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL21993054 | 0.88 | TOP2A (0.45) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL21993256 | 0.86 | KDM4E (0.48) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL21993047 | 0.84 | KMT2A (0.52) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL21992969 | 0.81 | KDM4E (0.52) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL21993051 | 0.80 | KDM4E (0.57) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL21992933 | 0.79 | KDM4E (0.50) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL21992985 | 0.79 | KDM4E (0.54) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL21993056 | 0.78 | KDM4E (0.57) | KDM4EMAPTALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11141402-B2 | Compounds useful in inhibiting human trefoil factor 3 | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2021-10-12 | — | — | US | disclosed |
| US-20200147039-A1 | COMPOUNDS USEFUL IN INHIBITING HUMAN TREFOIL FACTOR 3 | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11141402-B2 | Compounds useful in inhibiting human trefoil factor 3 | ETF1, F3, DNASE1L3 | KDM4E 3966/4885MAPT 4590/4885ALDH1A1 3051/4885 |
| US-20200147039-A1 | COMPOUNDS USEFUL IN INHIBITING HUMAN TREFOIL FACTOR 3 | ETF1, F3, DNASE1L3 | KDM4E 3966/4885MAPT 4590/4885ALDH1A1 3051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.