Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | TOP2A | P11388 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MYB | P10242 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21993415 | 0.94 | KDM4E (0.62) | KMT2AKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL21992986 | 0.89 | KDM4E (0.56) | KMT2AKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL21992930 | 0.89 | KDM4E (0.65) | KMT2AKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL21992973 | 0.87 | MAPT (0.58) | KMT2AKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL21993237 | 0.87 | KMT2A (0.61) | KMT2AKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL21993259 | 0.87 | MAPT (0.60) | KMT2AKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL21993446 | 0.85 | MAPT (0.58) | KMT2AKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL21992947 | 0.85 | MAPT (0.58) | KMT2AKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL21992972 | 0.84 | KDM4E (0.59) | KMT2AKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL21993260 | 0.83 | MAPT (0.77) | KMT2AKDM4EMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11141402-B2 | Compounds useful in inhibiting human trefoil factor 3 | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2021-10-12 | — | — | US | disclosed |
| US-20200147039-A1 | COMPOUNDS USEFUL IN INHIBITING HUMAN TREFOIL FACTOR 3 | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11141402-B2 | Compounds useful in inhibiting human trefoil factor 3 | ETF1, F3, DNASE1L3 | KMT2A 4155/4885KDM4E 3966/4885MAPT 4590/4885 |
| US-20200147039-A1 | COMPOUNDS USEFUL IN INHIBITING HUMAN TREFOIL FACTOR 3 | ETF1, F3, DNASE1L3 | KMT2A 4155/4885KDM4E 3966/4885MAPT 4590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.