Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.48 |
| ▸ | MEN1 | O00255 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TOP2A | P11388 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | USP7 | Q93009 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21992998 | 0.93 | KMT2A (0.50) | KMT2AMEN1ALDH1A1TOP2AKDM4E | |
| SCHEMBL21993454 | 0.93 | KMT2A (0.48) | KMT2AMEN1ALDH1A1TOP2AKDM4E | |
| SCHEMBL21992974 | 0.92 | KMT2A (0.47) | KMT2AMEN1ALDH1A1TOP2AKDM4E | |
| SCHEMBL21993279 | 0.92 | MAPT (0.57) | KMT2AMEN1ALDH1A1TOP2AKDM4E | |
| SCHEMBL21993288 | 0.91 | KDM4E (0.48) | KMT2AMEN1ALDH1A1TOP2AKDM4E | |
| SCHEMBL21993267 | 0.86 | TOP2A (0.53) | KMT2AMEN1ALDH1A1TOP2AKDM4E | |
| SCHEMBL21992926 | 0.83 | MAPT (0.52) | KMT2AMEN1ALDH1A1TOP2AKDM4E | |
| SCHEMBL21993251 | 0.83 | MAPT (0.54) | KMT2AMEN1ALDH1A1TOP2AKDM4E | |
| SCHEMBL21993419 | 0.83 | KDM4E (0.54) | KMT2AMEN1ALDH1A1TOP2AKDM4E | |
| SCHEMBL21992989 | 0.82 | KMT2A (0.58) | KMT2AMEN1ALDH1A1TOP2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11141402-B2 | Compounds useful in inhibiting human trefoil factor 3 | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2021-10-12 | — | — | US | disclosed |
| US-20200147039-A1 | COMPOUNDS USEFUL IN INHIBITING HUMAN TREFOIL FACTOR 3 | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11141402-B2 | Compounds useful in inhibiting human trefoil factor 3 | ETF1, F3, DNASE1L3 | KMT2A 4155/4885MEN1 2137/4885ALDH1A1 3051/4885 |
| US-20200147039-A1 | COMPOUNDS USEFUL IN INHIBITING HUMAN TREFOIL FACTOR 3 | ETF1, F3, DNASE1L3 | KMT2A 4155/4885MEN1 2137/4885ALDH1A1 3051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.