Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 18/20 | 0.78 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | GABRP | O00591 | 1/20 | 0.62 |
| ▸ | GABRD | O14764 | 1/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.62 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.62 |
| ▸ | PGR | P06401 | 1/20 | 0.62 |
| ▸ | KLK3 | P07288 | 1/20 | 0.62 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.62 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.62 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.62 |
| ▸ | CNR1 | P21554 | 1/20 | 0.62 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.62 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.62 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.62 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.62 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.62 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.62 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21350025 | 0.91 | AR (0.79) | ARABCG2HDAC1GABRPGABRD | |
| SCHEMBL21996132 | 0.90 | AR (0.66) | ARPGR | |
| SCHEMBL7035063 | 0.90 | AR (0.87) | ARABCG2HDAC1GABRPGABRD | |
| SCHEMBL1715463 | 0.89 | AR (0.82) | ARABCG2HDAC1GABRPGABRD | |
| SCHEMBL1716086 | 0.88 | AR (0.84) | ARABCG2HDAC1GABRPGABRD | |
| SCHEMBL1715956 | 0.88 | AR (1.00) | ARABCG2HDAC1GABRPGABRD | |
| SCHEMBL547391 | 0.88 | AR (0.84) | ARABCG2HDAC1GABRPGABRD | |
| SCHEMBL1715951 | 0.87 | AR (0.82) | ARABCG2HDAC1GABRPGABRD | |
| SCHEMBL14218798 | 0.87 | AR (0.82) | ARABCG2HDAC1GABRPGABRD | |
| SCHEMBL29094457 | 0.87 | AR (0.82) | ARABCG2HDAC1GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11292782-B2 | Diarylhydantoin compounds and methods of use thereof | NUVATION BIO INC. (US) | 2022-04-05 | — | — | US | disclosed |
| US-11292782-B2 | Diarylhydantoin compounds and methods of use thereof | NUVATION BIO INC. (US) | 2022-04-05 | — | — | US | disclosed |
| EP-3886853-A1 | DIARYLHYDANTOIN COMPOUNDS AND METHODS OF USE THEREOF | Nuvation Bio Inc. (US) | 2021-10-06 | — | — | EP | disclosed |
| US-20200199098-A1 | DIARYLHYDANTOIN COMPOUNDS AND METHODS OF USE THEREOF | SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) | 2020-06-25 | — | — | US | disclosed |
| US-20200199098-A1 | DIARYLHYDANTOIN COMPOUNDS AND METHODS OF USE THEREOF | SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) | 2020-06-25 | — | — | US | disclosed |
| WO-2020113088-A1 | DIARYLHYDANTOIN COMPOUNDS AND METHODS OF USE THEREOF | NUVATION BIO INC. (US) | 2020-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200199098-A1 | DIARYLHYDANTOIN COMPOUNDS AND METHODS OF USE THEREOF | SHBG, NCOA3, NCOA1 | AR 9/4885ABCG2 244/4885HDAC1 222/4885 |
| US-11292782-B2 | Diarylhydantoin compounds and methods of use thereof | SHBG, NCOA3, NCOA1 | AR 9/4885ABCG2 244/4885HDAC1 222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.