SCHEMBL21996430

SCHEMBL21996430

CC(C)(C)OC(=O)N1CCC(F)C12CC2Br

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.36
CHRM1 P11229 1/20 0.36
CHRM3 P20309 1/20 0.36
HPGD P15428 1/20 0.36
EPHX2 P34913 1/20 0.36
GPR119 Q8TDV5 2/20 0.35
USP2 O75604 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
RECQL P46063 1/20 0.35
EPHX1 P07099 1/20 0.35
PREP P48147 1/20 0.33
ROCK2 O75116 1/20 0.33
ELANE P08246 1/20 0.33
GRIN2B Q13224 1/20 0.32
GRIN2C Q14957 1/20 0.32
KDM1A O60341 1/20 0.32
DDB1 Q16531 1/20 0.32
CRBN Q96SW2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22047130 0.78 CHRM2 (0.38) CHRM2CHRM1CHRM3HPGDEPHX2
SCHEMBL21996530 0.78 CHRM2 (0.36) CHRM2CHRM1CHRM3HPGDEPHX2
SCHEMBL21996524 0.77 HPGD (0.40) CHRM2CHRM1CHRM3HPGDEPHX2
SCHEMBL28170943 0.77 CHRM2 (0.37) CHRM2CHRM1CHRM3HPGDEPHX2
SCHEMBL22047542 0.77 HPGD (0.40) CHRM2CHRM1CHRM3HPGDEPHX2
SCHEMBL22394916 0.74 CHRM2 (0.37) CHRM2CHRM1CHRM3HPGDEPHX2
SCHEMBL4484103 0.71 KDM1A (0.38) CHRM2CHRM1CHRM3HPGDEPHX2
SCHEMBL25348423 0.71 ALDH1A1 (0.35) CHRM2CHRM1CHRM3HPGDGPR119
SCHEMBL25348886 0.71 ALDH1A1 (0.35) CHRM2CHRM1CHRM3HPGDGPR119
SCHEMBL25348801 0.71 ALDH1A1 (0.35) CHRM2CHRM1CHRM3HPGDGPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020113077-A9 COMPOSITIONS AND METHODS FOR MODULAR CONTROL OF BIOORTHOGONAL LIGATION THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2020-08-13 WO disclosed
WO-2020113077-A1 COMPOSITIONS AND METHODS FOR MODULAR CONTROL OF BIOORTHOGONAL LIGATION THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2020-06-04 WO disclosed