Sugi Predict

Sugi Predict / Compounds / SCHEMBL2199657

SCHEMBL2199657

SCHEMBL2199657

Cc1ccc(O[Si](C)(C)C(C)(C)C)cc1C=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA12 O43570 4/20 0.48
▸ CA1 P00915 4/20 0.48
▸ CA9 Q16790 4/20 0.48
▸ PREP P48147 4/20 0.42
▸ ERN1 O75460 1/20 0.38
▸ ALDH1A1 P00352 4/20 0.37
▸ TSHR P16473 1/20 0.37
▸ HSP90AA1 P07900 1/20 0.34
▸ HSP90AB1 P08238 1/20 0.34
▸ TRIM24 O15164 1/20 0.34
▸ TYR P14679 1/20 0.34
▸ TRIM33 Q9UPN9 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.32
▸ GRIA1 P42261 1/20 0.32
▸ GRIA2 P42262 1/20 0.32
▸ GRIA3 P42263 1/20 0.32
▸ GRIA4 P48058 1/20 0.32
▸ LMNA P02545 1/20 0.31
▸ CYP1A2 P05177 1/20 0.30
▸ CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22078670 0.89 CA12 (0.47) CA12CA1CA9PREPERN1
SCHEMBL14240879 0.83 CA12 (0.48) CA12CA1CA9PREPERN1
SCHEMBL1070012 0.83 CA12 (0.48) CA12CA1CA9PREPERN1
SCHEMBL6841139 0.83 CA12 (0.48) CA12CA1CA9PREPERN1
SCHEMBL31587586 0.82 ERN1 (0.60) CA12CA1CA9ERN1TRIM24
SCHEMBL29993848 0.82 CA12 (0.47) CA12CA1CA9PREPERN1
SCHEMBL1620647 0.82 CA12 (0.47) CA12CA1CA9PREPERN1
SCHEMBL15124515 0.82 CA12 (0.47) CA12CA1CA9PREPERN1
SCHEMBL19810818 0.82 ALDH1A1 (0.49) CA12CA1CA9PREPERN1
SCHEMBL14697028 0.82 ERN1 (0.60) CA12CA1CA9ERN1TRIM24

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1846402-B1 3-AMINO-PYRAZOLO[3,4B]PYRIDINES USED AS INHIBITORS OF PROTEIN TYROSINE KINASES FOR TREATING ANGIOGENIC, HYPERPROLIFERATIVE OR NEURODEGENERATIVE DISEASES BAYER IP GMBH (DE) 2014-02-26 — — EP disclosed
US-7977325-B2 3-amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents BAYER SCHERING PHARMA AG (DE) 2011-07-12 — — US disclosed
US-7977325-B2 3-amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents BAYER SCHERING PHARMA AG (DE) 2011-07-12 — — US disclosed
US-20090030010-A1 3-Amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents GENESYS CLOUD SERVICES, INC. 2009-01-29 — — US disclosed
US-20090030010-A1 3-Amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents GENESYS CLOUD SERVICES, INC. 2009-01-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090030010-A1 3-Amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents MAP4K2, ABL1, MAP4K3 CA12 4776/4885CA1 4381/4885CA9 4368/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.