Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15751249 | 0.91 | SIGMAR1 (0.53) | SIGMAR1CCR5ALDH1A1ENPP2CHRM5 | |
| SCHEMBL21998108 | 0.86 | SIGMAR1 (0.49) | SIGMAR1CCR5ALDH1A1ENPP2CHRM5 | |
| SCHEMBL31734241 | 0.86 | SIGMAR1 (0.49) | SIGMAR1CCR5ALDH1A1ENPP2CHRM5 | |
| SCHEMBL21997212 | 0.86 | SIGMAR1 (0.49) | SIGMAR1CCR5ALDH1A1ENPP2CHRM5 | |
| SCHEMBL22835656 | 0.85 | SIGMAR1 (0.48) | SIGMAR1CCR5ALDH1A1ENPP2CHRM5 | |
| SCHEMBL26351438 | 0.85 | SIGMAR1 (0.48) | SIGMAR1CCR5ALDH1A1ENPP2CHRM5 | |
| SCHEMBL21997413 | 0.85 | SIGMAR1 (0.48) | SIGMAR1CCR5ALDH1A1ENPP2CHRM5 | |
| SCHEMBL1058888 | 0.85 | SIGMAR1 (0.60) | SIGMAR1CCR5ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL27866758 | 0.84 | SIGMAR1 (0.51) | SIGMAR1CCR5ALDH1A1ENPP2CHRM5 | |
| SCHEMBL21997646 | 0.83 | SIGMAR1 (0.47) | SIGMAR1CCR5ALDH1A1ENPP2CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3886904-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2021-10-06 | — | — | EP | disclosed |
| WO-2020113233-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-06-04 | — | — | WO | disclosed |