Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 19/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 19/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26099448 | 0.78 | CRBN (0.53) | DDB1CRBNALDH1A1CHRM2OPRM1 | |
| SCHEMBL21997875 | 0.77 | CRBN (0.45) | DDB1CRBN | |
| SCHEMBL29077504 | 0.76 | CRBN (0.49) | DDB1CRBNALDH1A1CHRM2OPRM1 | |
| SCHEMBL22836025 | 0.74 | CRBN (0.50) | DDB1CRBNALDH1A1CHRM2OPRM1 | |
| SCHEMBL26272283 | 0.73 | CRBN (0.61) | DDB1CRBNIKZF3 | |
| SCHEMBL21997352 | 0.72 | CRBN (0.56) | DDB1CRBNIKZF3 | |
| SCHEMBL21996914 | 0.72 | DDB1 (0.65) | DDB1CRBNALDH1A1CHRM2OPRM1 | |
| SCHEMBL24607915 | 0.72 | CRBN (0.58) | DDB1CRBNALDH1A1CHRM2OPRM1 | |
| SCHEMBL29751610 | 0.72 | CRBN (0.58) | DDB1CRBNALDH1A1CHRM2OPRM1 | |
| SCHEMBL26447957 | 0.72 | DDB1 (0.58) | DDB1CRBNALDH1A1CHRM2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3886904-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2021-10-06 | — | — | EP | disclosed |
| WO-2020113233-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-06-04 | — | — | WO | disclosed |