Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 12/20 | 0.45 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.36 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21069325 | 0.86 | PDK4 (0.50) | CRBNDDB1JAK1PDK4 | |
| SCHEMBL26099448 | 0.85 | CRBN (0.53) | CRBNDDB1IKZF1IKZF2 | |
| SCHEMBL21998134 | 0.83 | CRBN (0.48) | CRBNDDB1MEN1KMT2A | |
| SCHEMBL29347198 | 0.82 | PDK4 (0.49) | CRBNDDB1JAK1PDK4 | |
| SCHEMBL24607909 | 0.79 | CRBN (0.48) | CRBNDDB1PDK4 | |
| SCHEMBL29751470 | 0.79 | CRBN (0.48) | CRBNDDB1PDK4 | |
| SCHEMBL29612778 | 0.78 | CRBN (0.43) | CRBNDDB1MEN1KMT2A | |
| SCHEMBL30225550 | 0.78 | CRBN (0.43) | CRBNDDB1MEN1KMT2A | |
| SCHEMBL30733874 | 0.78 | CRBN (0.42) | CRBNDDB1 | |
| SCHEMBL21997877 | 0.77 | DDB1 (0.46) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3886904-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2021-10-06 | — | — | EP | disclosed |
| EP-3731869-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |
| WO-2020113233-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-06-04 | — | — | WO | disclosed |