Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.74 |
| ▸ | AKT2 | P31751 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.51 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12156506 | 0.91 | AKT1 (0.62) | AKT1AKT2TDP1L3MBTL1KDM4E | |
| SCHEMBL4750642 | 0.89 | AKT1 (0.60) | AKT1AKT2TDP1L3MBTL1KDM4E | |
| SCHEMBL14278952 | 0.88 | AKT1 (0.68) | AKT1AKT2TDP1L3MBTL1KDM4E | |
| SCHEMBL12721780 | 0.86 | AKT1 (0.57) | AKT1AKT2TDP1L3MBTL1KDM4E | |
| SCHEMBL12721863 | 0.86 | AKT1 (0.57) | AKT1AKT2TDP1L3MBTL1KDM4E | |
| SCHEMBL13727536 | 0.86 | KIF11 (0.67) | AKT1AKT2TDP1L3MBTL1KDM4E | |
| SCHEMBL12690677 | 0.85 | AKT1 (0.56) | AKT1AKT2TDP1L3MBTL1KDM4E | |
| SCHEMBL8011433 | 0.85 | AKT1 (0.56) | AKT1AKT2TDP1L3MBTL1KDM4E | |
| SCHEMBL4605370 | 0.85 | AKT1 (1.00) | AKT1AKT2TDP1L3MBTL1KDM4E | |
| SCHEMBL13726280 | 0.84 | KIF11 (0.73) | AKT1AKT2TDP1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200148682-A1 | AKT ISOZYME-SPECIFIC COVALENT INHIBITORS DERIVED FROM REDOX-SIGNALING LIPIDS | CORNELL UNIVERSITY | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200148682-A1 | AKT ISOZYME-SPECIFIC COVALENT INHIBITORS DERIVED FROM REDOX-SIGNALING LIPIDS | AKT1, ROS1, AKT3 | AKT1 1/4885AKT2 4/4885TDP1 3025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.