Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 13/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19079503 | 0.88 | SMYD3 (0.53) | SMYD3HDAC3HDAC1STAT3STAT1 | |
| SCHEMBL19079510 | 0.88 | SMYD3 (0.53) | SMYD3HDAC3HDAC1STAT3STAT1 | |
| SCHEMBL19079509 | 0.82 | RAB9A (0.53) | SMYD3HDAC3HDAC1STAT3STAT1 | |
| SCHEMBL19079497 | 0.82 | SMYD3 (0.52) | SMYD3HDAC3HDAC1STAT3STAT1 | |
| SCHEMBL19079484 | 0.82 | STAT1 (0.57) | SMYD3HDAC3HDAC1STAT3STAT1 | |
| SCHEMBL17594849 | 0.78 | SMYD3 (0.66) | SMYD3HDAC3HDAC1RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL17594406 | 0.77 | SMYD3 (0.65) | SMYD3HDAC3HDAC1RAB9ANPC1 | |
| SCHEMBL19079499 | 0.77 | SMYD3 (0.53) | SMYD3HDAC3HDAC1STAT1RAB9A | |
| SCHEMBL19079469 | 0.76 | STAT1 (0.59) | SMYD3HDAC3HDAC1STAT3STAT1 | |
| SCHEMBL19079461 | 0.75 | SMYD3 (0.61) | SMYD3STAT3STAT1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200148650-A1 | ISOXAZOLE CARBOXAMIDE COMPOUNDS | Epizyme, Inc. | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200148650-A1 | ISOXAZOLE CARBOXAMIDE COMPOUNDS | SMYD3, SMYD2, SNRPD3 | SMYD3 1/4885HDAC3 318/4885HDAC1 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.