Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31754779 | 1.00 | SYK (0.41) | SYKSSTR4ATRAAK1NPC1 | |
| SCHEMBL26986587 | 0.93 | SYK (0.38) | SYKSSTR4ATRAAK1NPC1 | |
| SCHEMBL3335527 | 0.84 | NPC1 (0.49) | SYKSSTR4AAK1NPC1RAB9A | |
| SCHEMBL24035707 | 0.83 | SYK (0.41) | SYKSSTR4ATRAAK1NPC1 | |
| SCHEMBL1353862 | 0.83 | SYK (0.41) | SYKSSTR4ATRAAK1NPC1 | |
| SCHEMBL30161746 | 0.83 | SYK (0.41) | SYKSSTR4ATRAAK1NPC1 | |
| SCHEMBL27047963 | 0.81 | SYK (0.46) | SYKSSTR4ATRAAK1NPC1 | |
| SCHEMBL13302732 | 0.81 | SYK (0.40) | SYKSSTR4ATRAAK1NPC1 | |
| SCHEMBL18620983 | 0.80 | SYK (0.33) | SYKNPC1RAB9APDPK1USP30 | |
| SCHEMBL22000176 | 0.80 | KDM4E (0.48) | SYKATRNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024009232-A1 | SUBSTITUTED N-(PYRIDIN-2-YL)ACETAMIDE DERIVATIVES AS CDK12/13 INHIBITORS | AURIGENE ONCOLOGY LIMITED (IN) | 2024-01-11 | — | — | WO | disclosed |
| US-11059786-B2 | Aminopyridine compounds and methods for the preparation and use thereof | Cortexyme, Inc. (US) | 2021-07-13 | — | — | US | disclosed |
| US-20200148642-A1 | AMINOPYRIDINE COMPOUNDS AND METHODS FOR THE PREPARATION AND USE THEREOF | Cortexyme, Inc. (US) | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200148642-A1 | AMINOPYRIDINE COMPOUNDS AND METHODS FOR THE PREPARATION AND USE THEREOF | ENPEP, DNPEP, ANPEP | SYK 2561/4885SSTR4 3304/4885ATR 1968/4885 |
| US-11059786-B2 | Aminopyridine compounds and methods for the preparation and use thereof | ENPEP, DNPEP, ANPEP | SYK 2561/4885SSTR4 3304/4885ATR 1968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.