Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 11/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2201101 | 1.00 | METAP2 (0.55) | METAP2LRRK2ADORA3ADORA2AADORA1 | |
| SCHEMBL2200786 | 0.93 | METAP2 (0.55) | METAP2LRRK2ADORA3ADORA2AADORA1 | |
| SCHEMBL2203342 | 0.93 | METAP2 (0.55) | METAP2LRRK2ADORA3ADORA2AADORA1 | |
| SCHEMBL2198189 | 0.91 | METAP2 (0.61) | METAP2LRRK2ADORA3ADORA2AADORA1 | |
| SCHEMBL2198182 | 0.91 | METAP2 (0.61) | METAP2LRRK2ADORA3ADORA2AADORA1 | |
| SCHEMBL2202512 | 0.89 | METAP2 (0.57) | METAP2LRRK2 | |
| SCHEMBL2198551 | 0.89 | METAP2 (0.52) | METAP2LRRK2ADORA3ADORA2AADORA1 | |
| SCHEMBL2198538 | 0.89 | METAP2 (0.52) | METAP2LRRK2ADORA3ADORA2AADORA1 | |
| SCHEMBL2202518 | 0.89 | METAP2 (0.57) | METAP2LRRK2 | |
| SCHEMBL2201059 | 0.87 | METAP2 (0.73) | METAP2ADORA3ADORA2AADORA1FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912994-B1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-03-12 | — | — | EP | claimed |
| US-7977343-B2 | Adenine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-12 | — | — | US | claimed |
| EP-1912994-B1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-03-12 | — | — | EP | disclosed |