Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.70 |
| ▸ | CDK6 | Q00534 | 15/20 | 0.70 |
| ▸ | CDK1 | P06493 | 14/20 | 0.70 |
| ▸ | CDK2 | P24941 | 14/20 | 0.70 |
| ▸ | CCNB1 | P14635 | 10/20 | 0.70 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.70 |
| ▸ | CDK9 | P50750 | 8/20 | 0.70 |
| ▸ | CDK7 | P50613 | 7/20 | 0.70 |
| ▸ | CCND3 | P30281 | 4/20 | 0.70 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.70 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.70 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.70 |
| ▸ | EGFR | P00533 | 2/20 | 0.70 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.70 |
| ▸ | BRAF | P15056 | 2/20 | 0.70 |
| ▸ | KDR | P35968 | 2/20 | 0.70 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.70 |
| ▸ | CCNH | P51946 | 2/20 | 0.70 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.70 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22004033 | 1.00 | CDK4 (0.70) | CDK4CDK6CDK1CDK2CCNB1 | |
| SCHEMBL22004034 | 1.00 | CDK4 (0.70) | CDK4CDK6CDK1CDK2CCNB1 | |
| SCHEMBL22004026 | 0.96 | CDK4 (0.71) | CDK4CDK6CDK1CDK2CCNB1 | |
| SCHEMBL22004025 | 0.96 | CDK4 (0.71) | CDK4CDK6CDK1CDK2CCNB1 | |
| SCHEMBL22004027 | 0.96 | CDK4 (0.71) | CDK4CDK6CDK1CDK2CCNB1 | |
| SCHEMBL22003364 | 0.96 | CDK4 (0.72) | CDK4CDK6CDK1CDK2CCNB1 | |
| SCHEMBL22003363 | 0.96 | CDK4 (0.72) | CDK4CDK6CDK1CDK2CCNB1 | |
| SCHEMBL22003362 | 0.96 | CDK4 (0.72) | CDK4CDK6CDK1CDK2CCNB1 | |
| SCHEMBL17488787 | 0.92 | CDK4 (0.78) | CDK4CDK6CDK1CDK2CCNB1 | |
| SCHEMBL17488710 | 0.92 | CDK4 (0.78) | CDK4CDK6CDK1CDK2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11179391-B2 | Compound with kinase inhibitory activity and preparation method and use thereof | Zhang, Fuyao (CN) | 2021-11-23 | — | — | US | disclosed |
| US-20200155550-A1 | COMPOUND WITH KINASE INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREOF | SHANGHAI BEST-LINK BIOSCIENCE, LLC (CN) | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155550-A1 | COMPOUND WITH KINASE INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREOF | CDK9, CDK7, CDK6 | CDK4 14/4885CDK6 3/4885CDK1 5/4885 |
| US-11179391-B2 | Compound with kinase inhibitory activity and preparation method and use thereof | CDK9, CDK7, CDK6 | CDK4 14/4885CDK6 3/4885CDK1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.