Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.70 |
| ▸ | CDK2 | P24941 | 16/20 | 0.70 |
| ▸ | CDK6 | Q00534 | 16/20 | 0.70 |
| ▸ | CDK1 | P06493 | 12/20 | 0.70 |
| ▸ | CDK7 | P50613 | 7/20 | 0.70 |
| ▸ | CDK9 | P50750 | 7/20 | 0.70 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.65 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.65 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.65 |
| ▸ | CCND3 | P30281 | 3/20 | 0.65 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.65 |
| ▸ | EGFR | P00533 | 2/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.65 |
| ▸ | BRAF | P15056 | 2/20 | 0.65 |
| ▸ | KDR | P35968 | 2/20 | 0.65 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.65 |
| ▸ | CCNH | P51946 | 2/20 | 0.65 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.65 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22003480 | 0.94 | CDK4 (0.68) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL22003567 | 0.93 | CDK4 (0.72) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL21795786 | 0.92 | CDK4 (0.74) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL22004039 | 0.92 | CDK4 (0.71) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL22003488 | 0.92 | CDK4 (0.65) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL22004035 | 0.91 | CDK4 (0.65) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL22004022 | 0.91 | CDK4 (0.63) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL22003478 | 0.91 | CDK4 (0.68) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL22003704 | 0.91 | CDK4 (0.72) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL22004919 | 0.90 | CDK4 (0.62) | CDK4CDK2CDK6CDK1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11179391-B2 | Compound with kinase inhibitory activity and preparation method and use thereof | Zhang, Fuyao (CN) | 2021-11-23 | — | — | US | disclosed |
| EP-3620456-B1 | COMPOUND WITH KINASE INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREOF | ZHANG FUYAO (CN) | 2021-11-17 | — | — | EP | disclosed |
| US-20200155550-A1 | COMPOUND WITH KINASE INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREOF | SHANGHAI BEST-LINK BIOSCIENCE, LLC (CN) | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155550-A1 | COMPOUND WITH KINASE INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREOF | CDK9, CDK7, CDK6 | CDK4 14/4885CDK2 7/4885CDK6 3/4885 |
| US-11179391-B2 | Compound with kinase inhibitory activity and preparation method and use thereof | CDK9, CDK7, CDK6 | CDK4 14/4885CDK2 7/4885CDK6 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.