Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 17/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 16/20 | 0.41 |
| ▸ | CASP1 | P29466 | 16/20 | 0.41 |
| ▸ | CASP7 | P55210 | 16/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 15/20 | 0.41 |
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.39 |
| ▸ | HPGD | P15428 | 7/20 | 0.39 |
| ▸ | USP2 | O75604 | 11/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 4/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20231888 | 0.83 | CRBN (0.50) | CYP1A2ALDH1A1TSHR | |
| SCHEMBL30892113 | 0.83 | CRBN (0.50) | CYP1A2ALDH1A1TSHR | |
| SCHEMBL22006091 | 0.80 | CRBN (0.39) | CYP1A2ALDH1A1CASP1 | |
| SCHEMBL22297288 | 0.72 | CRBN (0.57) | CYP1A2ALDH1A1TSHR | |
| SCHEMBL845434 | 0.69 | CRBN (0.57) | CYP1A2ALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL30892104 | 0.67 | CRBN (0.56) | CYP1A2ALDH1A1TSHR | |
| SCHEMBL18263933 | 0.65 | CRBN (0.55) | CYP1A2ALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL3125601 | 0.65 | CRBN (0.55) | CYP1A2ALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL27099145 | 0.64 | CRBN (0.54) | CYP1A2ALDH1A1TSHR | |
| SCHEMBL9684472 | 0.64 | ALDH1A1 (0.46) | CYP1A2ALDH1A1CASP1CASP7HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200155690-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155690-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | CRBN, CBL, MDM2 | CYP1A2 4681/4885ALDH1A1 3671/4885CASP1 3634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.