Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | BLM | P54132 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | APAF1 | O14727 | 2/20 | 0.48 |
| ▸ | TDP2 | O95551 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24340284 | 0.94 | MAPK1 (0.47) | DHODHMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL24799102 | 0.89 | MAPK1 (0.50) | DHODHMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL22007538 | 0.89 | DHODH (0.42) | DHODHMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL19175545 | 0.82 | CDC25B (0.39) | DHODHMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL19175646 | 0.82 | APEX1 (0.49) | DHODHMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL31972 | 0.80 | MAPK1 (0.43) | DHODHMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL12921593 | 0.78 | APEX1 (0.53) | MAPTSMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL19336229 | 0.78 | APEX1 (0.53) | MAPTSMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL25471186 | 0.77 | MAPK1 (0.41) | DHODHMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14439375 | 0.76 | APAF1 (0.56) | DHODHMAPTSMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200155609-A1 | COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING PTEN INHIBITORS | TRANSFUSION HEALTH LLC | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155609-A1 | COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING PTEN INHIBITORS | PTEN, MCL1, PIK3CA | DHODH 1394/4885MAPT 4692/4885SMN1; SMN2 1752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.