Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2259269 | 0.89 | ALOX5AP (0.49) | ALOX5APFEN1F2RL3 | |
| SCHEMBL2200755 | 0.87 | CHRNB4 (0.58) | ALOX5APFEN1F2RL3OPRD1 | |
| SCHEMBL3113607 | 0.86 | DPP4 (0.52) | ALOX5APFEN1F2RL3OPRD1FFAR1 | |
| SCHEMBL29007980 | 0.86 | DPP4 (0.48) | ALOX5APFEN1F2RL3SSTR4OPRD1 | |
| SCHEMBL21845257 | 0.86 | ALOX5AP (0.50) | ALOX5APFEN1F2RL3 | |
| SCHEMBL29960520 | 0.86 | ALOX5AP (0.50) | ALOX5APFEN1F2RL3 | |
| SCHEMBL7412041 | 0.86 | ALOX5AP (0.50) | ALOX5APFEN1F2RL3 | |
| SCHEMBL13419700 | 0.85 | ALOX5AP (0.51) | ALOX5APFEN1F2RL3 | |
| SCHEMBL5154892 | 0.85 | ALOX5AP (0.47) | ALOX5APFEN1F2RL3 | |
| SCHEMBL2539185 | 0.84 | F2RL3 (0.50) | ALOX5APFEN1F2RL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912994-B1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-03-12 | — | — | EP | disclosed |
| US-7977343-B2 | Adenine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-12 | — | — | US | disclosed |
| US-20100160352-A1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160352-A1 | ADENINE DERIVATIVES | HSP90AA1, TRAP1, HSP90AB1 | ALOX5AP 3894/4885FEN1 1767/4885F2RL3 3775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.