Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfisoxazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 13/20 | 0.97 |
| ▸ | EDNRB | P24530 | 9/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfisoxazole SCHEMBL23467 | 0.98 | EDNRA (1.00) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| Sulfisoxazole SCHEMBL788644 | 0.98 | EDNRA (1.00) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| Sulfisoxazole SCHEMBL5917298 | 0.97 | EDNRA (0.97) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| Sulfisoxazole SCHEMBL5959142 | 0.94 | EDNRA (0.92) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| Sulfisoxazole SCHEMBL16097888 | 0.93 | EDNRA (0.89) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| Sulfisoxazole SCHEMBL3221114 | 0.90 | EDNRA (0.82) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| Sulfisoxazole SCHEMBL20770061 | 0.88 | EDNRA (0.81) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| Sulfisoxazole SCHEMBL4973236 | 0.88 | EDNRA (0.81) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| Sulfisoxazole SCHEMBL28264710 | 0.88 | EDNRA (0.81) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| Sulfisoxazole SCHEMBL887764 | 0.87 | EDNRA (0.79) | EDNRAEDNRBMEN1CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240115652-A1 | TISSUE OCCLUDING AGENT COMPRISING AN IEIKIEIKIEIKI PEPTIDE | 3 D MATRIX LTD (JP) | 2024-04-11 | — | — | US | claimed |
| US-11801281-B2 | Tissue occluding agent comprising an ieikieikieiki peptide | 3-D MATRIX, LTD. (JP) | 2023-10-31 | — | — | US | claimed |
| EP-4183425-A1 | TISSUE PLUG | 3-D Matrix Ltd. (JP) | 2023-05-24 | — | — | EP | claimed |
| US-20220193184-A1 | TISSUE OCCLUDING AGENT COMPRISING AN IEIKIEIKIEIKI PEPTIDE | 3-D MATRIX, LTD. (JP) | 2022-06-23 | — | — | US | claimed |
| EP-3800197-A1 | TISSUE PLUG | 3-D Matrix Ltd. (JP) | 2021-04-07 | — | — | EP | claimed |
| EP-3470093-B1 | TISSUE PLUG | 3 D MATRIX LTD (JP) | 2020-08-19 | — | — | EP | claimed |
| US-20200222496-A1 | TISSUE OCCLUDING AGENT | 3-D MATRIX, LTD. (JP) | 2020-07-16 | — | — | US | claimed |
| US-10596225-B2 | Tissue occluding agent comprising an IEIKIEIKIEIKI peptide | 3-D MATRIX, LTD. (JP) | 2020-03-24 | — | — | US | claimed |
| US-10576123-B2 | Tissue occluding agent comprising an IEIKIEIKIEIKI peptide | 3-D MATRIX, LTD. (JP) | 2020-03-03 | — | — | US | claimed |
| EP-3470093-A1 | TISSUE PLUG | 3-D Matrix Ltd. (JP) | 2019-04-17 | — | — | EP | claimed |
| EP-3238749-B1 | TISSUE PLUG | 3 D MATRIX LTD (JP) | 2018-09-19 | — | — | EP | claimed |
| EP-3238749-A1 | TISSUE PLUG | 3-D Matrix Ltd. (JP) | 2017-11-01 | — | — | EP | claimed |
| US-20140038909-A1 | TISSUE OCCLUDING AGENT | 3-D MATRIX, LTD. (JP) | 2014-02-06 | — | — | US | claimed |
| US-20110201541-A1 | TISSUE OCCLUDING AGENT | 3-D MATRIX, LTD. (JP) | 2011-08-18 | — | — | US | claimed |
| EP-2345433-A1 | TISSUE PLUG | 3-D Matrix, Ltd. (JP) | 2011-07-20 | — | — | EP | claimed |
| US-20240115652-A1 | TISSUE OCCLUDING AGENT COMPRISING AN IEIKIEIKIEIKI PEPTIDE | 3 D MATRIX LTD (JP) | 2024-04-11 | — | — | US | disclosed |
| US-11801281-B2 | Tissue occluding agent comprising an ieikieikieiki peptide | 3-D MATRIX, LTD. (JP) | 2023-10-31 | — | — | US | disclosed |
| US-20110201541-A1 | TISSUE OCCLUDING AGENT | 3-D MATRIX, LTD. (JP) | 2011-08-18 | — | — | US | disclosed |
| EP-2345433-A1 | TISSUE PLUG | 3-D Matrix, Ltd. (JP) | 2011-07-20 | — | — | EP | disclosed |
| EP-2030612-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING BURNS (VARIANTS) AND A METHOD FOR THE PRODUCTION THEREOF (VARIANTS) | Rasnetsov, Lev Davidovich (RU) | 2009-03-04 | — | — | EP | disclosed |