Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.45 |
| ▸ | SRC | P12931 | 5/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.42 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.42 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | ABL2 | P42684 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31684335 | 1.00 | BTK (0.45) | BTKSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL21965625 | 1.00 | BTK (0.45) | BTKSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL20645511 | 0.95 | BTK (0.45) | BTKSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL31684306 | 0.95 | BTK (0.45) | BTKSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL21903578 | 0.91 | BTK (0.46) | BTKSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL20645478 | 0.91 | BTK (0.46) | BTKSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL21579420 | 0.86 | EGFR (0.48) | BTKSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL21903722 | 0.86 | JAK2 (0.48) | BTKSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL22009062 | 0.86 | JAK2 (0.48) | BTKSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL6274546 | 0.86 | EGFR (0.48) | BTKSRCPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3653626-A1 | NOVEL 1H-PYRAZOLOPYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Daewoong Pharmaceutical Co., Ltd. (KR) | 2020-05-20 | — | — | EP | disclosed |
| CN-110914266-A | Novel 1H-pyrazolopyridine derivative and pharmaceutical composition comprising the same | 株式会社大熊制药 | 2020-03-24 | — | — | CN | disclosed |