Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17130913 | 1.00 | MAPT (0.42) | MAPTALDH1A1HCAR2SLC6A2SLC6A4 | |
| SCHEMBL18269645 | 0.78 | MAPT (0.44) | MAPTALDH1A1HCAR2 | |
| SCHEMBL8987060 | 0.77 | MAPT (0.51) | MAPTALDH1A1HCAR2L3MBTL1TTR | |
| SCHEMBL22009230 | 0.76 | SLC6A2 (0.42) | MAPTALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17130912 | 0.76 | SLC6A2 (0.42) | MAPTALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17131035 | 0.76 | SLC6A2 (0.42) | MAPTALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28035371 | 0.76 | SLC6A2 (0.34) | HCAR2SLC6A2SLC6A4SLC6A3ADRB2 | |
| SCHEMBL22009153 | 0.75 | L3MBTL1 (0.44) | MAPTHCAR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17130986 | 0.75 | L3MBTL1 (0.44) | MAPTHCAR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL352366 | 0.74 | HTR2A (0.41) | ALDH1A1SLC6A2SLC6A4SLC6A3ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122747-B1 | DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS | NORTH & SOUTH BROTHER PHARMACY INVESTMENT CO LTD (CN) | 2020-05-20 | — | — | EP | disclosed |