Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 9/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2201025 | 1.00 | METAP2 (0.57) | METAP2ADORA3ADORA2AADORA1FFAR2 | |
| SCHEMBL2200406 | 0.92 | METAP2 (0.57) | METAP2ADORA3ADORA2AADORA1FFAR2 | |
| SCHEMBL2200096 | 0.92 | METAP2 (0.57) | METAP2ADORA3ADORA2AADORA1FFAR2 | |
| SCHEMBL2201244 | 0.89 | METAP2 (0.71) | METAP2ADORA3ADORA2AADORA1FFAR2 | |
| SCHEMBL2201241 | 0.89 | METAP2 (0.71) | METAP2ADORA3ADORA2AADORA1FFAR2 | |
| SCHEMBL2200372 | 0.89 | METAP2 (0.57) | METAP2ADORA3ADORA2AADORA1CHRNB4 | |
| SCHEMBL2200408 | 0.89 | METAP2 (0.57) | METAP2ADORA3ADORA2AADORA1CHRNB4 | |
| SCHEMBL2200916 | 0.89 | METAP2 (0.56) | METAP2ADORA3ADORA2AADORA1FFAR2 | |
| SCHEMBL2200911 | 0.89 | METAP2 (0.56) | METAP2ADORA3ADORA2AADORA1FFAR2 | |
| SCHEMBL3602228 | 0.89 | METAP2 (0.56) | METAP2ADORA3ADORA2AADORA1FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912994-B1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-03-12 | — | — | EP | claimed |
| US-7977343-B2 | Adenine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-12 | — | — | US | claimed |