Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 13/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22010440 | 0.92 | KRAS (0.50) | KRAS | |
| SCHEMBL25021124 | 0.90 | KRAS (0.48) | KRASLMNAHPGDALDH1A1MAPT | |
| SCHEMBL22010331 | 0.89 | KRAS (0.47) | KRASLMNAHPGDALDH1A1MAPT | |
| SCHEMBL25020030 | 0.88 | KRAS (0.56) | KRAS | |
| SCHEMBL22010611 | 0.87 | KRAS (0.47) | KRASLMNAHPGDALDH1A1MAPT | |
| SCHEMBL22010320 | 0.86 | KRAS (0.59) | KRAS | |
| SCHEMBL21912770 | 0.86 | KRAS (0.67) | KRAS | |
| SCHEMBL22010332 | 0.85 | KRAS (0.48) | KRAS | |
| SCHEMBL22010613 | 0.84 | KRAS (0.49) | KRAS | |
| SCHEMBL22010618 | 0.84 | KRAS (0.49) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020101736-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-05-22 | — | — | WO | disclosed |