Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.41 |
| ▸ | F10 | P00742 | 8/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 2/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22010636 | 0.88 | F2 (0.39) | F2F10PRSS1CA12CA1 | |
| SCHEMBL21962905 | 0.81 | F2 (0.49) | F2F10PRSS1CA12CA1 | |
| SCHEMBL22010634 | 0.80 | F2 (0.41) | F2F10PRSS1CA12CA1 | |
| SCHEMBL21962961 | 0.78 | F2 (0.47) | F2F10PRSS1CA12CA1 | |
| SCHEMBL25829889 | 0.71 | MEN1 (0.43) | F2PRSS1CA12CA1CA2 | |
| SCHEMBL22076564 | 0.70 | F2 (0.51) | F2F10PRSS1LOXL2POLB | |
| SCHEMBL21962932 | 0.68 | KDM4E (0.47) | CA12CA1CA2CA9 | |
| SCHEMBL21962887 | 0.68 | KDM4E (0.43) | CA12CA1CA2CA9 | |
| SCHEMBL22280038 | 0.66 | LOXL2 (0.47) | CA12CA1CA2CA9LOXL2 | |
| SCHEMBL4446181 | 0.66 | LOXL2 (0.62) | CA12CA1CA2CA9LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880666-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-06-28 | — | — | EP | disclosed |
| WO-2020102100-A9 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2022-01-06 | — | — | WO | disclosed |
| WO-2020102100-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |