Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 17/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22002684 | 0.97 | NLRP3 (0.45) | NLRP3ALDH1A1ATMSMN1; SMN2 | |
| SCHEMBL21893841 | 0.84 | NLRP3 (0.46) | NLRP3ALDH1A1ATMSMN1; SMN2 | |
| SCHEMBL25031407 | 0.83 | NLRP3 (0.46) | NLRP3ALDH1A1ATMSMN1; SMN2 | |
| SCHEMBL25031965 | 0.83 | NLRP3 (0.38) | NLRP3ALDH1A1ATMSMN1; SMN2 | |
| SCHEMBL23481781 | 0.82 | NLRP3 (0.37) | NLRP3ALDH1A1ATMSMN1; SMN2 | |
| SCHEMBL22002748 | 0.82 | NLRP3 (0.48) | NLRP3ALDH1A1ATMSMN1; SMN2 | |
| SCHEMBL25033694 | 0.78 | NLRP3 (0.44) | NLRP3ALDH1A1ATMSMN1; SMN2 | |
| SCHEMBL22002808 | 0.77 | NLRP3 (0.44) | NLRP3ALDH1A1ATMSMN1; SMN2 | |
| SCHEMBL21893007 | 0.77 | — | — | |
| SCHEMBL21892963 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154499-A1 | SULFONIMIDAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-07-30 | — | — | WO | disclosed |
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |