SCHEMBL22012728

CC(C)c1cc(F)cc(C(C)CCC(C)c2cc(F)cc(C(C)C)c2NC(=O)N=S(N)(=O)c2ncc(C(C)(C)O)s2)c1NC(=O)N=S(N)(=O)c1cc(C(C)(C)O)cs1

nearest known ligand 0.30

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	NLRP3	Q96P20	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL21893707	0.87	NLRP3 (0.31)	NLRP3
SCHEMBL20692042	0.87	NLRP3 (0.31)	NLRP3
SCHEMBL26007194	0.87	NLRP3 (0.31)	NLRP3
SCHEMBL23482180	0.85	NLRP3 (0.36)	NLRP3
SCHEMBL26007201	0.85	NLRP3 (0.36)	NLRP3
SCHEMBL20692358	0.85	NLRP3 (0.36)	NLRP3
SCHEMBL20692288	0.83	NLRP3 (0.35)	NLRP3
SCHEMBL25033411	0.83	NLRP3 (0.30)	NLRP3
SCHEMBL20692180	0.79	NLRP3 (0.31)	NLRP3
SCHEMBL20692448	0.78	NLRP3 (0.40)	NLRP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2020102576-A1	COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY	NOVARTIS INFLAMMASOME RESEARCH, INC. (US)	2020-05-22	—	—	WO	disclosed