Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | KDM4A | O75164 | 1/20 | 0.51 |
| ▸ | KDM5A | P29375 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.51 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 3/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | MLYCD | O95822 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200556 | 0.99 | ALOX5 (0.61) | ALOX5MAPTRXFP1KDM4AKDM5A | |
| SCHEMBL2201636 | 0.94 | ALOX5 (0.55) | ALOX5MAPTKDM4ENPY5RMLYCD | |
| SCHEMBL2202823 | 0.88 | KDM4E (0.62) | ALOX5KDM4ENPY5RMLYCDKMT2A | |
| SCHEMBL8010609 | 0.83 | ALOX5 (0.60) | ALOX5MAPTRXFP1KDM4AKDM5A | |
| SCHEMBL8000964 | 0.83 | ALOX5 (0.60) | ALOX5MAPTRXFP1KDM4AKDM5A | |
| SCHEMBL8695755 | 0.83 | ALOX5 (0.63) | ALOX5MAPTRXFP1KDM4AKDM5A | |
| SCHEMBL2202453 | 0.79 | KDM4E (0.54) | ALOX5MAPTKDM4CKDM4ECES1 | |
| SCHEMBL16353651 | 0.79 | KDM4E (0.46) | KDM4ENPY5RTBXAS1KMT2A | |
| SCHEMBL16658765 | 0.79 | ALOX5 (0.75) | ALOX5MAPTRXFP1KDM4AKDM5A | |
| SCHEMBL16658768 | 0.79 | ALOX5 (0.75) | ALOX5MAPTRXFP1KDM4AKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | AMGEN INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | ALOX5 3036/4885MAPT 173/4885RXFP1 4731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.