SCHEMBL22013237

SCHEMBL22013237

CC(C)(C)OC(=O)NCc1nc2cc(Br)ccc2[nH]1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1H O95180 2/20 0.53
CACNA1B Q00975 1/20 0.53
CACNA1C Q13936 1/20 0.53
BCHE P06276 1/20 0.46
KDM4A O75164 1/20 0.41
TSHR P16473 1/20 0.41
MAPK10 P53779 1/20 0.41
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40
CACNA1G O43497 1/20 0.39
PTPN1 P18031 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30103105 0.91 CACNA1H (0.53) CACNA1HCACNA1BCACNA1CBCHEKDM4A
SCHEMBL23731882 0.91 CACNA1H (0.53) CACNA1HCACNA1BCACNA1CBCHEKDM4A
SCHEMBL30313258 0.87 CACNA1H (0.54) CACNA1HCACNA1BCACNA1CBCHEKDM4A
SCHEMBL29613729 0.86 CACNA1H (0.53) CACNA1HCACNA1BCACNA1CBCHEKDM4A
SCHEMBL22775707 0.86 CACNA1H (0.53) CACNA1HCACNA1BCACNA1CBCHEKDM4A
SCHEMBL4149629 0.86 CACNA1H (0.53) CACNA1HCACNA1BCACNA1CBCHEKDM4A
SCHEMBL24507620 0.85 CACNA1H (0.52) CACNA1HCACNA1BCACNA1CBCHEKDM4A
SCHEMBL38661238 0.85 CACNA1H (0.52) CACNA1HCACNA1BCACNA1CBCHETSHR
SCHEMBL29615656 0.85 CACNA1H (0.52) CACNA1HCACNA1BCACNA1CBCHEKDM4A
SCHEMBL1507162 0.84 CACNA1H (0.51) CACNA1HCACNA1BCACNA1CBCHEKDM4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3882246-A1 MONOBACTAM COMPOUNDS AND USE THEREFOR Nanjing Sanhome Pharmaceutical Co., Ltd. (CN) 2021-09-22 EP disclosed
WO-2020098635-A1 MONOBACTAM COMPOUNDS AND USE THEREFOR 南京圣和药业股份有限公司 2020-05-22 WO disclosed