Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HPN | P05981 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24507620 | 1.00 | CACNA1H (0.52) | CACNA1HCACNA1BCACNA1CTSHRCYP1A2 | |
| SCHEMBL1507162 | 0.90 | CACNA1H (0.51) | CACNA1HCACNA1BCACNA1CTSHRMAPK10 | |
| SCHEMBL15173223 | 0.87 | BRD4 (0.49) | CACNA1HCACNA1BCACNA1CCYP1A2BCHE | |
| SCHEMBL30313258 | 0.86 | CACNA1H (0.54) | CACNA1HCACNA1BCACNA1CTSHRCYP1A2 | |
| SCHEMBL4149629 | 0.85 | CACNA1H (0.53) | CACNA1HCACNA1BCACNA1CTSHRMAPK10 | |
| SCHEMBL22013237 | 0.85 | CACNA1H (0.53) | CACNA1HCACNA1BCACNA1CTSHRMAPK10 | |
| SCHEMBL29613729 | 0.85 | CACNA1H (0.53) | CACNA1HCACNA1BCACNA1CTSHRMAPK10 | |
| SCHEMBL22775707 | 0.85 | CACNA1H (0.53) | CACNA1HCACNA1BCACNA1CTSHRMAPK10 | |
| SCHEMBL38661238 | 0.84 | CACNA1H (0.52) | CACNA1HCACNA1BCACNA1CTSHRCYP1A2 | |
| SCHEMBL38662380 | 0.83 | CACNA1B (0.65) | CACNA1HCACNA1BCACNA1CTSHRMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4259607-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2023-10-18 | — | — | EP | disclosed |
| CN-116745267-A | Benzimidazole derivatives for the treatment of respiratory diseases | 跨膜蛋白16A有限公司 | 2023-09-12 | — | — | CN | disclosed |
| WO-2022123314-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2022-06-16 | — | — | WO | disclosed |