SCHEMBL22013361 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	NTRK1	P04629	7/20	0.38

▸	NTRK3	Q16288	1/20	0.35

▸	MET	P08581	8/20	0.35

▸	JAK2	O60674	5/20	0.34

▸	JAK1	P23458	1/20	0.34

▸	JAK3	P52333	1/20	0.34

▸	MAP4K3	Q8IVH8	1/20	0.33

▸	FGFR1	P11362	1/20	0.33

▸	FGFR2	P21802	1/20	0.33

▸	FGFR3	P22607	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL29692837	0.93	MET (0.40)	NTRK1NTRK3METJAK2MAP4K3
SCHEMBL22013657	0.93	MET (0.40)	NTRK1NTRK3METJAK2MAP4K3
SCHEMBL22013172	0.92	NTRK1 (0.40)	NTRK1NTRK3METJAK2JAK1
SCHEMBL23825257	0.89	NTRK1 (0.37)	NTRK1METJAK2JAK1JAK3
SCHEMBL22013394	0.89	NTRK1 (0.37)	NTRK1METJAK2JAK1JAK3
SCHEMBL22013395	0.89	NTRK1 (0.37)	NTRK1METJAK2JAK1JAK3
SCHEMBL29692827	0.89	NTRK1 (0.39)	NTRK1NTRK3METJAK2JAK1
SCHEMBL22013164	0.89	NTRK1 (0.39)	NTRK1NTRK3METJAK2JAK1
SCHEMBL22013271	0.87	ALK (0.42)	NTRK1NTRK3METJAK2JAK1
SCHEMBL29692817	0.87	ALK (0.42)	NTRK1NTRK3METJAK2JAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2020098723-A1	SIX-MEMBERED AND SIX-MEMBERED HETEROCYCLIC COMPOUND AND USES THEREOF SERVING AS PROTEIN RECEPTOR KINASE INHIBITOR	上海轶诺药业有限公司	2020-05-22	—	—	WO	disclosed