Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 7/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.30 |
| ▸ | MYC | P01106 | 1/20 | 0.30 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.30 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23692319 | 0.88 | NLRP3 (0.35) | NLRP3HSD11B1NR1I2PSEN1PSEN2 | |
| SCHEMBL23692255 | 0.88 | NLRP3 (0.35) | NLRP3HSD11B1NR1I2PSEN1PSEN2 | |
| SCHEMBL20698735 | 0.88 | NLRP3 (0.35) | NLRP3HSD11B1NR1I2PSEN1PSEN2 | |
| SCHEMBL28405824 | 0.86 | NLRP3 (0.35) | NLRP3HSD11B1NR1I2ARPSEN1 | |
| SCHEMBL20699039 | 0.82 | NLRP3 (0.35) | NLRP3HSD11B1 | |
| SCHEMBL19508016 | 0.79 | NLRP3 (0.54) | NLRP3SOAT2MYCSOAT1MAP2K3 | |
| SCHEMBL20698833 | 0.77 | NLRP3 (0.31) | NLRP3HSD11B1 | |
| SCHEMBL20681225 | 0.77 | NLRP3 (0.46) | NLRP3HSD11B1SOAT2MYCSOAT1 | |
| SCHEMBL20681344 | 0.77 | NLRP3 (0.46) | NLRP3HSD11B1SOAT2MYCSOAT1 | |
| SCHEMBL29687550 | 0.77 | NLRP3 (0.46) | NLRP3HSD11B1SOAT2MYCSOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658538-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-04-19 | — | — | EP | disclosed |
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |