Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20698763 | 0.93 | NLRP3 (0.36) | NLRP3PTGS2PTGS1 | |
| SCHEMBL22014450 | 0.93 | NLRP3 (0.36) | NLRP3PTGS2PTGS1 | |
| SCHEMBL22014451 | 0.90 | — | — | |
| SCHEMBL22014724 | 0.90 | NLRP3 (0.32) | NLRP3 | |
| SCHEMBL23692104 | 0.88 | — | — | |
| SCHEMBL23668434 | 0.85 | NLRP3 (0.34) | NLRP3 | |
| SCHEMBL22014629 | 0.84 | NLRP3 (0.35) | NLRP3 | |
| SCHEMBL20699057 | 0.84 | NLRP3 (0.35) | NLRP3 | |
| SCHEMBL25067162 | 0.83 | NLRP3 (0.51) | NLRP3 | |
| SCHEMBL20699084 | 0.83 | NLRP3 (0.51) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |