Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22014818 | 0.89 | GAA (0.40) | GAAPOLBKDM4EMAPTMEN1 | |
| SCHEMBL24209508 | 0.81 | GAA (0.42) | GAAPOLBKDM4EMAPTMEN1 | |
| SCHEMBL24208966 | 0.80 | GAA (0.41) | GAAPOLBKDM4EMAPTMEN1 | |
| SCHEMBL23701474 | 0.77 | MAPT (0.50) | GAAPOLBKDM4EMAPTMEN1 | |
| SCHEMBL24209155 | 0.76 | ALDH1A1 (0.39) | POLBMAPTKMT2AALDH1A1LMNA | |
| SCHEMBL24209122 | 0.75 | KDM4E (0.38) | KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL23701395 | 0.73 | GAA (0.50) | GAAPOLBKDM4EMAPTMEN1 | |
| SCHEMBL23701397 | 0.73 | GAA (0.50) | GAAPOLBKDM4EMAPTMEN1 | |
| SCHEMBL23701368 | 0.72 | GAA (0.46) | GAAPOLBKDM4EMAPTMEN1 | |
| SCHEMBL23701371 | 0.72 | GAA (0.46) | GAAPOLBKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020099886-A1 | LOX INHIBITORS | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2020-05-22 | — | — | WO | disclosed |