SCHEMBL22014950

CC(C)c1cc2c(c(C(C)CCC(C)c3cc4c(c(C(C)C)c3CC(=O)N=S(N)(=O)c3sc(C(C)(C)O)cc3F)COC4)c1CC(=O)N=S(N)(=O)c1sc(C(C)(C)O)cc1F)COC2

nearest known ligand 0.32

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	NLRP3	Q96P20	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL22015058	0.95	NLRP3 (0.33)	NLRP3
SCHEMBL22014345	0.86	—	—
SCHEMBL22014349	0.86	—	—
SCHEMBL22014420	0.81	NLRP3 (0.31)	NLRP3
SCHEMBL22014361	0.81	—	—
SCHEMBL25067153	0.81	—	—
SCHEMBL20698763	0.78	NLRP3 (0.36)	NLRP3
SCHEMBL22014450	0.78	NLRP3 (0.36)	NLRP3
SCHEMBL25067162	0.77	NLRP3 (0.51)	NLRP3
SCHEMBL20699084	0.77	NLRP3 (0.51)	NLRP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2020102574-A1	THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY	NOVARTIS INFLAMMASOME RESEARCH, INC. (US)	2020-05-22	—	—	WO	disclosed