Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MBTD1 | Q05BQ5 | 5/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 12/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.41 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2201497 | 1.00 | KMT2A (0.43) | KMT2AMBTD1L3MBTL3L3MBTL1L3MBTL4 | |
| SCHEMBL2200316 | 0.99 | KMT2A (0.44) | KMT2AMBTD1L3MBTL3L3MBTL1L3MBTL4 | |
| SCHEMBL2200314 | 0.99 | KMT2A (0.44) | KMT2AMBTD1L3MBTL3L3MBTL1L3MBTL4 | |
| SCHEMBL2200600 | 0.92 | KMT2A (0.46) | KMT2AL3MBTL1HRH3LMNAMEN1 | |
| SCHEMBL2200597 | 0.92 | KMT2A (0.46) | KMT2AL3MBTL1HRH3LMNAMEN1 | |
| SCHEMBL2200656 | 0.92 | EPHX2 (0.47) | KMT2AL3MBTL3L3MBTL1LMNAMEN1 | |
| SCHEMBL2200653 | 0.92 | EPHX2 (0.47) | KMT2AL3MBTL3L3MBTL1LMNAMEN1 | |
| SCHEMBL12429457 | 0.91 | KMT2A (0.40) | KMT2AMBTD1L3MBTL3L3MBTL1L3MBTL4 | |
| SCHEMBL2202742 | 0.87 | KMT2A (0.50) | KMT2AMBTD1L3MBTL3L3MBTL1L3MBTL4 | |
| SCHEMBL2200189 | 0.87 | MCHR1 (0.42) | KMT2AL3MBTL1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |