Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200653 | 1.00 | EPHX2 (0.47) | EPHX2MCHR1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2200192 | 0.95 | MCHR1 (0.42) | EPHX2MCHR1KMT2AKDM4EALDH1A1 | |
| SCHEMBL12429475 | 0.95 | MCHR1 (0.42) | EPHX2MCHR1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2200189 | 0.95 | MCHR1 (0.42) | EPHX2MCHR1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2200184 | 0.95 | MCHR1 (0.42) | EPHX2MCHR1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2200314 | 0.92 | KMT2A (0.44) | EPHX2KMT2AMEN1L3MBTL1L3MBTL3 | |
| SCHEMBL2200316 | 0.92 | KMT2A (0.44) | EPHX2KMT2AMEN1L3MBTL1L3MBTL3 | |
| SCHEMBL2201497 | 0.92 | KMT2A (0.43) | KMT2ALMNAMEN1L3MBTL1L3MBTL3 | |
| SCHEMBL2201503 | 0.92 | KMT2A (0.43) | KMT2ALMNAMEN1L3MBTL1L3MBTL3 | |
| SCHEMBL2200600 | 0.89 | KMT2A (0.46) | KMT2AKDM4EALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20090029963-A1 | PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029963-A1 | PYRAZOL DERIVATIVES | CCR1, CCR3, CCRL2 | EPHX2 1452/4885MCHR1 606/4885KMT2A 4057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.