SCHEMBL22015657

SCHEMBL22015657

Cc1cccn2c(C(C)(C)NC=O)nc(C3CC3)c12

nearest known ligand 0.60

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 20/20 0.60
SSTR1 P30872 1/20 0.60
SSTR3 P32745 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22015549 0.87 SSTR4 (0.61) SSTR4SSTR1SSTR3
SCHEMBL22015969 0.82 SSTR4 (0.54) SSTR4SSTR1SSTR3
SCHEMBL17755102 0.80 SSTR4 (0.55) SSTR4SSTR1SSTR3
SCHEMBL17754839 0.79 SSTR4 (0.66) SSTR4SSTR1SSTR3
SCHEMBL19724490 0.76 SSTR4 (1.00) SSTR4SSTR1SSTR3
SCHEMBL16252717 0.76 SSTR4 (1.00) SSTR4SSTR1SSTR3
SCHEMBL18391436 0.74 SSTR4 (0.62) SSTR4SSTR1SSTR3
SCHEMBL22015960 0.74 SSTR4 (0.69) SSTR4SSTR1SSTR3
SCHEMBL19724438 0.74 SSTR4 (0.71) SSTR4SSTR1SSTR3
SCHEMBL16255973 0.74 SSTR4 (0.71) SSTR4SSTR1SSTR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3218372-B1 MORPHOLINE AND 1,4-OXAZEPANE AMIDES AS SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS BOEHRINGER INGELHEIM INT (DE) 2020-05-20 EP disclosed