Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.47 |
| ▸ | TP53 | P04637 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22015456 | 0.85 | KDM4E (0.46) | HDAC1HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL22015639 | 0.85 | MAPT (0.51) | HDAC1HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL22015461 | 0.84 | HDAC1 (0.49) | HDAC1HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL25713690 | 0.84 | KDM4E (0.51) | HDAC1HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL22015459 | 0.84 | MAPT (0.51) | HDAC1HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL22015466 | 0.83 | APP (0.53) | HDAC1HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL22015994 | 0.83 | MAPT (0.53) | HDAC1HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL22015453 | 0.83 | MAPT (0.50) | HDAC1HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL22015638 | 0.83 | PTGS1 (0.54) | HDAC1HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL22015837 | 0.81 | KDM4E (0.48) | HDAC1HDAC2HDAC8HDAC6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220017477-A1 | BENZOTHIAZOLE AND RELATED COMPOUNDS | SPINOGENIX, INC. | 2022-01-20 | — | — | US | disclosed |
| US-11117878-B2 | Benzothiazole and related compounds | SPINOGENIX, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200157068-A1 | BENZOTHIAZOLE AND RELATED COMPOUNDS | SPINOGENIX, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220017477-A1 | BENZOTHIAZOLE AND RELATED COMPOUNDS | BACE1, APP, BACE2 | HDAC1 4128/4885HDAC2 4567/4885HDAC8 4214/4885 |
| US-11117878-B2 | Benzothiazole and related compounds | BACE1, APP, BACE2 | HDAC1 4128/4885HDAC2 4567/4885HDAC8 4214/4885 |
| US-20200157068-A1 | BENZOTHIAZOLE AND RELATED COMPOUNDS | BACE1, APP, BACE2 | HDAC1 4128/4885HDAC2 4567/4885HDAC8 4214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.