Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 17/20 | 0.75 |
| ▸ | CCND1 | P24385 | 17/20 | 0.75 |
| ▸ | CDK2 | P24941 | 13/20 | 0.75 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.75 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.75 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.75 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.75 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.75 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.75 |
| ▸ | CDK9 | P50750 | 2/20 | 0.75 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.75 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.75 |
| ▸ | ABL1 | P00519 | 1/20 | 0.75 |
| ▸ | FYN | P06241 | 1/20 | 0.75 |
| ▸ | CDK1 | P06493 | 1/20 | 0.75 |
| ▸ | CSF1R | P07333 | 1/20 | 0.75 |
| ▸ | RET | P07949 | 1/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.75 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.75 |
| ▸ | MARK3 | P27448 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29508788 | 0.91 | CDK4 (0.61) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL22860140 | 0.90 | CDK4 (0.60) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL29508832 | 0.90 | CDK4 (0.62) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL29508870 | 0.90 | CDK4 (0.60) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL22860109 | 0.90 | CDK4 (0.62) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL29508813 | 0.90 | CDK4 (0.61) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL22860292 | 0.89 | CDK4 (0.59) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL29508857 | 0.89 | CDK4 (0.59) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL22860687 | 0.89 | CCND1 (0.58) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL29508816 | 0.89 | CCND1 (0.58) | CDK4CCND1CDK2CCNA2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220002293-A1 | 8-CYCLOPENTYL-7-OXO-2-(4-PIPERAZIN-1-YL-PHENYLAMINO)-7, 8-DIHYDRO-PYRIDO [2,3-D]PYRIMIDINE-6-CARBONITRILE AND USES THEREOF IN TREATING PROLIFERATIVE DISORDERS | ONCONOVA THERAPEUTICS, INC. (US) | 2022-01-06 | — | — | US | disclosed |
| CN-112969463-A | 8-cyclopentyl-7-oxo-2- (4-piperazin-1-yl-phenylamino) -7, 8-dihydro-pyrido [2,3-D ] pyrimidine-6-carbonitrile and its use in the treatment of proliferative diseases | 安哥洛华治疗公司 | 2021-06-15 | — | — | CN | disclosed |
| WO-2020101638-A1 | 8-CYCLOPENTYL-7-OXO-2-(4-PIPERAZIN-1-YL-PHENYLAMINO)-7, 8-DIHYDRO-PYRIDO [2,3-D]PYRIMIDINE-6-CARBONITRILE AND USES THEREOF IN TREATING PROLIFERATIVE DISORDERS | ONCONOVA THERAPEUTICS, INC. (US) | 2020-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220002293-A1 | 8-CYCLOPENTYL-7-OXO-2-(4-PIPERAZIN-1-YL-PHENYLAMINO)-7, 8-DIHYDRO-PYRIDO [2,3-D]PYRIMIDINE-6-CARBONITRILE AND USES THEREOF IN TREATING PROLIFERATIVE DISORDERS | DPYD, POLN, DCK | CDK4 8/4885CCND1 211/4885CDK2 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.