Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.58 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.58 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21952061 | 0.90 | TSHR (0.61) | TSHRAPOBEC3AAPOBEC3GCYP11B2CYP11B1 | |
| SCHEMBL30278739 | 0.90 | TSHR (0.61) | TSHRAPOBEC3AAPOBEC3GCYP11B2CYP11B1 | |
| SCHEMBL29798080 | 0.84 | CYP11B2 (0.58) | TSHRAPOBEC3AAPOBEC3GCYP11B2CYP11B1 | |
| SCHEMBL22016087 | 0.81 | TSHR (0.58) | TSHRAPOBEC3AAPOBEC3GLMNAMAPK1 | |
| SCHEMBL21952015 | 0.76 | TSHR (0.70) | TSHRAPOBEC3AAPOBEC3GLMNAMAPK1 | |
| SCHEMBL30278759 | 0.76 | TSHR (0.70) | TSHRAPOBEC3AAPOBEC3GLMNAMAPK1 | |
| SCHEMBL28669428 | 0.75 | TSHR (0.63) | TSHRAPOBEC3AAPOBEC3GLMNAMAPK1 | |
| SCHEMBL21952017 | 0.73 | TSHR (0.65) | TSHRAPOBEC3AAPOBEC3GLMNAMAPK1 | |
| SCHEMBL21952051 | 0.73 | TSHR (0.65) | TSHRAPOBEC3AAPOBEC3GLMNAMAPK1 | |
| SCHEMBL21951993 | 0.73 | TSHR (0.65) | TSHRAPOBEC3AAPOBEC3GLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020099652-A1 | COMPOUNDS THAT SELECTIVELY AND EFFECTIVELY INHIBIT HAKAI-MEDIATED UBIQUITINATION, AS ANTI-CANCER DRUGS | FUNDACIÓN PROFESOR NOVOA SANTOS (ES) | 2020-05-22 | — | — | WO | disclosed |