Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 4/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.32 |
| ▸ | ITGB7 | P26010 | 4/20 | 0.32 |
| ▸ | COMT | P21964 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14803746 | 0.83 | ITGB1 (0.36) | ITGB1ITGA4ITGB7COMTAR | |
| SCHEMBL20051302 | 0.75 | ITGB1 (0.34) | ITGB1ITGA4ITGB7AR | |
| SCHEMBL20051737 | 0.73 | AR (0.35) | ITGB1ITGA4ITGB7COMTAR | |
| SCHEMBL14818821 | 0.72 | AR (0.37) | ITGB1ITGA4ITGB7COMTAR | |
| SCHEMBL22017511 | 0.70 | AR (0.34) | ITGB1ITGA4ITGB7COMTAR | |
| SCHEMBL24437199 | 0.69 | COMT (0.40) | ITGB1ITGA4ITGB7COMTAR | |
| SCHEMBL1689752 | 0.69 | AR (0.35) | ITGB1ITGA4ITGB7COMTAR | |
| SCHEMBL20051827 | 0.67 | ITGB1 (0.37) | ITGB1ITGA4ITGB7COMTAR | |
| SCHEMBL15700364 | 0.66 | GRIA1 (0.35) | ITGB1ITGA4ITGB7COMTAR | |
| SCHEMBL22016779 | 0.63 | KDM4E (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | ITGB1 3359/4885ITGA4 3235/4885ITGB7 2700/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | ITGB1 3359/4885ITGA4 3235/4885ITGB7 2700/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | ITGB1 3359/4885ITGA4 3235/4885ITGB7 2700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.