Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.38 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 6/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14818821 | 0.81 | AR (0.37) | COMTITGB1ITGA4ITGB7AR | |
| SCHEMBL20051737 | 0.78 | AR (0.35) | COMTITGB1ITGA4ITGB7AR | |
| SCHEMBL1689752 | 0.78 | AR (0.35) | COMTITGB1ITGA4ITGB7AR | |
| SCHEMBL22017511 | 0.75 | AR (0.34) | COMTITGB1ITGA4ITGB7AR | |
| SCHEMBL14803746 | 0.75 | ITGB1 (0.36) | COMTITGB1ITGA4ITGB7AR | |
| SCHEMBL20051827 | 0.75 | ITGB1 (0.37) | COMTITGB1ITGA4ITGB7AR | |
| SCHEMBL21955382 | 0.74 | KDM4E (0.42) | MAPTKDM4EALDH1A1GLAGAA | |
| SCHEMBL15700364 | 0.74 | GRIA1 (0.35) | COMTITGB1ITGA4ITGB7AR | |
| SCHEMBL22932562 | 0.71 | NPC1 (0.46) | COMTMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL30606292 | 0.71 | GRIA1 (0.34) | TP53MAPTKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220152014-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | GILEAD SCIENCES, INC. (US) | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220152014-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | ITGB7, ITGB4, ITGA4 | COMT 4242/4885ITGB1 4/4885ITGA4 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.