Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 4/20 | 0.31 |
| ▸ | AXL | P30530 | 3/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20691568 | 0.80 | GSK3B (0.39) | GSK3BDYRK1APDE10ATRPM8JAK2 | |
| SCHEMBL21986904 | 0.78 | NTRK1 (0.37) | GSK3BDYRK1AJAK2JAK1NTRK1 | |
| SCHEMBL21986905 | 0.78 | NTRK1 (0.37) | GSK3BDYRK1AJAK2JAK1NTRK1 | |
| SCHEMBL20691569 | 0.78 | NTRK1 (0.37) | GSK3BDYRK1AJAK2JAK1NTRK1 | |
| Trifluoroacetic Acid SCHEMBL21986919 | 0.77 | GSK3B (0.38) | GSK3BDYRK1APDE10AEGLN1 | |
| Trifluoroacetic Acid SCHEMBL21986921 | 0.77 | GSK3B (0.38) | GSK3BDYRK1APDE10AEGLN1 | |
| Trifluoroacetic Acid SCHEMBL28435693 | 0.76 | KDM4E (0.32) | — | |
| SCHEMBL22053570 | 0.75 | NPSR1 (0.34) | — | |
| SCHEMBL21958277 | 0.75 | — | — | |
| SCHEMBL28792085 | 0.72 | GSK3B (0.37) | GSK3BDYRK1APDE10ATRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200157111-A1 | PIPERAZINE HETEROARYL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE OF SAME IN MEDICINE | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157111-A1 | PIPERAZINE HETEROARYL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE OF SAME IN MEDICINE | IKZF2, WEE1, NOTUM | GSK3B 1048/4885DYRK1A 4430/4885PDE10A 2707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.